Error Rate Analysis for Coded Multicarrier Systems over Quasi-Static Fading Channels

This paper presents two methods for approximating the performance of coded multicarrier systems operating over frequency-selective, quasi-static fading channels with non-ideal interleaving. The first method is based on approximating the performance of the system over each realization of the channel, and is suitable for obtaining the outage performance of this type of system. The second method is based on knowledge of the correlation matrix of the frequency-domain channel gains and can be used to directly obtain the average performance. Both of the methods are applicable for convolutionally-coded interleaved systems employing Quadrature Amplitude Modulation (QAM). As examples, both methods are used to study the performance of the Multiband Orthogonal Frequency Division Multiplexing (OFDM) proposal for high data-rate Ultra-Wideband (UWB) communication.Comment: 5 pages, 3 figures, 2 tables. Submitted to Globecom 200

Performance Analysis and Enhancement of Multiband OFDM for UWB Communications

In this paper, we analyze the frequency-hopping orthogonal frequency-division multiplexing (OFDM) system known as Multiband OFDM for high-rate wireless personal area networks (WPANs) based on ultra-wideband (UWB) transmission. Besides considering the standard, we also propose and study system performance enhancements through the application of Turbo and Repeat-Accumulate (RA) codes, as well as OFDM bit-loading. Our methodology consists of (a) a study of the channel model developed under IEEE 802.15 for UWB from a frequency-domain perspective suited for OFDM transmission, (b) development and quantification of appropriate information-theoretic performance measures, (c) comparison of these measures with simulation results for the Multiband OFDM standard proposal as well as our proposed extensions, and (d) the consideration of the influence of practical, imperfect channel estimation on the performance. We find that the current Multiband OFDM standard sufficiently exploits the frequency selectivity of the UWB channel, and that the system performs in the vicinity of the channel cutoff rate. Turbo codes and a reduced-complexity clustered bit-loading algorithm improve the system power efficiency by over 6 dB at a data rate of 480 Mbps.Comment: 32 pages, 10 figures, 1 table. Submitted to the IEEE Transactions on Wireless Communications (Sep. 28, 2005). Minor revisions based on reviewers' comments (June 23, 2006

Cosmological Implications of the Tetron Model of Elementary Particles

Based on a possible solution to the tetron spin problem, a modification of the standard Big Bang scenario is suggested, where the advent of a spacetime manifold is connected to the appearance of tetronic bound states. The metric tensor is constructed from tetron constituents and the reason for cosmic inflation is elucidated. Furthermore, there are natural dark matter candidates in the tetron model. The ratio of ordinary to dark matter in the universe is calculated to be 1:5.Comment: 23 page

The EU´s political communication : communicating achievements to citizens in a changing environment : a cross-sectional-study involving Germany and Portugal

In view of the significant developments that the European Union’s (EU) political environment has undergone, this study aims at examining whether it’s institutions have adapted their political communication efforts credibly. The decade of 2008 to 2018 gave birth to fundamental environmental changes and major crisis confronting European liberal democracies and the whole Union. The digital transformation, the Eurozone and refugee crises and the rise of populist euroscepticism have changed the way citizens perceive the EU. The fact that most research in this field was conducted before this decade makes it urgent to examine the status-quo of the institutions communication and answer this study’s research question: Are the EU’s political communication actions up-to-date with the latest developments? To answer this, the study examines the developments in Germany and Portugal, that, being traditionally pro-European countries, were significantly affected by the different developments. Consisting of a two-step-analysis, the study includes a qualitative content analysis of the EU institutions’ awareness campaigns in 2018/2019 and a SWOT-analysis for the mid- to long term perspectives. The central finding of this study is that although the EU institutions are using the right tools to communicate to citizens they have missed out to confront the main drivers for euroscepticism and therefore reach citizens who are not yet convinced of the European project

Do Patent Pools Encourage Innovation? Evidence from the 19th-Century Sewing Machine Industry

Members of a patent pool agree to use a set of patents as if they were jointly owned by all members and license them as a package to other firms. Regulators favor pools as a means to encourage innovation: Pools are expected to reduce litigation risks for their members and lower license fees and transactions costs for other firms. This paper uses the example of the first patent pool in U.S. history, the Sewing Machine Combination (1856-1877) to perform the first empirical test of the effects of a patent pool on innovation. Contrary to theoretical predictions, the sewing machine pool appears to have discouraged patenting and innovation, in particular for the members of the pool. Data on stitches per minute, as an objectively quantifiable measure of innovation, confirm these findings. Innovation for both members and outside firms slowed as soon as the pool had been established and resumed only after it had dissolved.

Common Supplements Found To Lower Circulating Inflammation Levels

Glucosamine and chondroitin are popular non-vitamin dietary supplements used for osteoarthritis. Long-term use is associated with lower incidence of colorectal and lung cancers and with lower mortality; however, the mechanism underlying these observations is unknown. In vitro and animal studies show that glucosamine and chondroitin inhibit NF-kB, a central mediator of inflammation, but no definitive trials have been done in healthy humans.We conducted a randomized, double-blind, placebo-controlled, cross-over study to assess the effects of glucosamine hydrochloride (1500 mg/d) plus chondroitin sulfate (1200 mg/d) for 28 days compared to placebo in 18 (9 men, 9 women) healthy, overweight (body mass index 25.0-32.5 kg/m2) adults, aged 20-55 y. We examined 4 serum inflammatory biomarkers: C-reactive protein (CRP), interleukin 6, and soluble tumor necrosis factor receptors I and II; a urinary inflammation biomarker: prostaglandin E2-metabolite; and a urinary oxidative stress biomarker: F2-isoprostane. Plasma proteomics on an antibody array was performed to explore other pathways modulated by glucosamine and chondroitin.Serum CRP concentrations were 23% lower after glucosamine and chondroitin compared to placebo (P = 0.048). There were no significant differences in other biomarkers. In the proteomics analyses, several pathways were significantly different between the interventions after Bonferroni correction, the most significant being a reduction in the "cytokine activity" pathway (P = 2.6 x 10-16), after glucosamine and chondroitin compared to placebo.Glucosamine and chondroitin supplementation may lower systemic inflammation and alter other pathways in healthy, overweight individuals. This study adds evidence for potential mechanisms supporting epidemiologic findings that glucosamine and chondroitin are associated with reduced risk of lung and colorectal cancer.ClinicalTrials.gov NCT01682694

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis. Mitogen-activated protein kinase (MAPK) phosphorylation of proteins including connexin 43 (Cx43) has been associated with VSMC proliferation in atherosclerosis.</p> <p>Objective: To investigate whether MAPK phosphorylation of Cx43 is directly involved in VSMC proliferation.</p> <p>Methods and Results: We show in vivo that MAPK-phosphorylated Cx43 forms complexes with the cell cycle control proteins cyclin E and cyclin-dependent kinase 2 (CDK2) in carotids of apolipoprotein-E receptor null (ApoE−/−) mice and in C57Bl/6 mice treated with platelet-derived growth factor–BB (PDGF). We tested the involvement of Cx43 MAPK phosphorylation in vitro using constructs for full-length Cx43 (Cx43) or the Cx43 C-terminus (Cx43CT) and produced null phosphorylation Ser>Ala (Cx43MK4A/Cx43CTMK4A) and phospho-mimetic Ser>Asp (Cx43MK4D/Cx43CTMK4D) mutations. Coimmunoprecipitation studies in primary VSMC isolated from Cx43 wild-type (Cx43+/+) and Cx43 null (Cx43−/−) mice and analytic size exclusion studies of purified proteins identify that interactions between cyclin E and Cx43 requires Cx43 MAPK phosphorylation. We further demonstrate that Cx43 MAPK phosphorylation is required for PDGF-mediated VSMC proliferation. Finally, using a novel knock-in mouse containing Cx43-MK4A mutation, we show in vivo that interactions between Cx43 and cyclin E are lost and VSMC proliferation does not occur after treatment of carotids with PDGF and that neointima formation is significantly reduced in carotids after injury.</p> <p>Conclusions: We identify MAPK-phosphorylated Cx43 as a novel interacting partner of cyclin E in VSMC and show that this interaction is critical for VSMC proliferation. This novel interaction may be important in the development of atherosclerotic lesions.</p&gt